It’s also recommended to avoid grapefruit juice when taking other medications, too. Err on the side of caution and restrict drinking and eating grapefruit if you take one of these statins, at least until you discuss the risks with your doctor. No one has the same reaction when mixing grapefruit with lovastatin, atorvastatin, or simvastatin. However, check with your doctor if you experience ill effects, since it’s unclear how common these interactions are. If you accidentally consume a small amount of grapefruit, it isn’t likely to affect your medication. Most incidents of negative reactions involved consuming large amounts of grapefruit. Keep in mind that both fresh and frozen juices have the same effect.Īccording to the Cleveland Clinic, there are instance when consuming moderate amounts of grapefruit appear to be safe. Others may need to consume more of the fruit or juice to have an interaction. Just one grapefruit or one glass of grapefruit juice could be enough to cause an interaction in some people. The exact amount of grapefruit it takes to have a negative reaction when taking lovastatin, atorvastatin, or simvastatin is unknown. How much grapefruit is ok while on certain statins?
Which medications should not be taken with grapefruit skin#
If you use a skin patch or receive your medication through an injection, you may have a lower risk of adverse effects.
This is because the interaction happens in your digestive tract. Interestingly, the interaction between grapefruit and medications poses a danger only when taken orally. Grapefruit doesn’t affect other statins because they are metabolized by a different enzyme, CYP2C9. This compound deactivates the CYP3A4 enzyme that the body uses to metabolize, or process, these particular statins. Furanocoumarins are organic chemical compounds present in many different plants, including grapefruit.
The secret to the interaction between grapefruit and these statins is in furanocoumarins, according to a 2017 study. You only need to avoid grapefruit if your doctor prescribes lovastatin, atorvastatin, or simvastatin. For this reason, you might avoid the fruit altogether. One misconception is that you shouldn’t mix grapefruit with any statin drug. If you’re prescribed a statin, it’s important to understand which ones can interact negatively with grapefruit and grapefruit juice. How grapefruit interacts with certain statins
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